Sirolimus (Rapamycin) 5mg, 10 Tablets — TM Siroash

Siroash 5 (Sirolimus / Rapamycin) — 10 Tablets (1 Blister)

Siroash 5 is a high-dose sirolimus (rapamycin) formulation marketed by the Indian pharmaceutical enterprise Asher Pharmaceuticals. This product listing offers a single blister pack containing 10 tablets, providing a convenient, high-strength layout for advanced anti-aging and longevity dosing protocols.

General Pharmaceutical & Manufacturer Information

• Brand Name: Siroash 5
• Active Ingredient: Sirolimus (historically known as Rapamycin)
• Dosage: 5 mg of Sirolimus per tablet
• Package Size: 1 Blister (10 tablets)
• CAS Number: 53123-88-9
• Molecular Formula: C51H79NO13
• Pharmacological Class: Selective Mechanistic Target of Rapamycin (mTOR) inhibitor
• Marketed By: Asher Pharmaceuticals, Pune, India
• Company Profile: Asher Pharmaceuticals is an Indian-based pharmaceutical enterprise involved in sourcing, marketing, and commercializing high-quality generic drugs, therapeutic formulations, and niche life-extension compounds under stringent quality regulatory guidelines to meet international market demands.

Anti-Aging & Longevity Properties (Geroprotection)

In modern longevity medicine, sirolimus (rapamycin) is recognized as one of the most thoroughly researched and promising geroprotectors. Rather than merely masking the superficial signs of aging, it targets the fundamental cellular mechanisms driven by the aging process.

• 1. mTORC1 Pathway Inhibition: The mTOR complex regulates cell growth and metabolism. Over time, its chronic hyperactivation leads to the accumulation of cellular waste and accelerated tissue aging. Siroash 5 downregulates overactive mTORC1 signaling, mimicking the biological benefits of caloric restriction to slow down the pace of biological aging.
• 2. Activation of Autophagy: By inhibiting the mTOR pathway, the drug triggers autophagy—the cell's natural "recycling" system. This process clears out damaged proteins, dysfunctional mitochondria, and toxic metabolic debris, effectively rejuvenating tissues at a cellular level.
• 3. Reduction of Systemic Inflammation (SASP): Rapamycin effectively suppresses the Senescence-Associated Secretory Phenotype (SASP). It reduces the production of pro-inflammatory cytokines by senescent ("zombie") cells, thereby mitigating inflammaging—the chronic, low-grade inflammation that underlies most age-related diseases.
• 4. Metabolic and Cognitive Preservation: In longevity regimens, sirolimus is utilized to help optimize insulin sensitivity, support cardiovascular health against age-related arterial stiffness, and maintain neuroplasticity to protect the brain from cognitive decline.

Administration in Longevity Protocols

Unlike its high-dose daily use in transplantation medicine, anti-aging protocols typically employ rapamycin in intermittent, low-dose schedules (e.g., 5 mg taken once weekly or every two weeks). The 5 mg dosage form is highly practical for individuals whose targeted protocols require a higher baseline single-dose entry point, minimizing the need to take multiple lower-strength tablets at once. This pulse-dosing strategy maximizes geroprotective benefits while avoiding chronic immune suppression.

For Research Applications Only. This product is supplied for laboratory and research use only and is not intended to diagnose, treat, cure, or prevent any disease. The use of sirolimus for longevity purposes should always be conducted under the supervision of a qualified anti-aging specialist or physician, alongside regular blood work panels (including lipid profiles, glucose levels, and complete blood counts).