Sirolimus (Rapamycin) 3mg, 10 Tablets — TM Siroash

Siroash 3 (Sirolimus / Rapamycin) — 10 Tablets (1 Blister)

Siroash 3 is a premium sirolimus (rapamycin) formulation marketed by the Indian pharmaceutical company Asher Pharmaceuticals. This product listing offers a single blister pack containing 10 tablets, providing a precise and convenient layout for tailoring specific anti-aging and longevity dosing regimens.

General Pharmaceutical & Manufacturer Information

• Brand Name: Siroash 3
• Active Ingredient: Sirolimus (historically known as Rapamycin)
• Dosage: 3 mg of Sirolimus per tablet
• Package Size: 1 Blister (10 tablets)
• CAS Number: 53123-88-9
• Molecular Formula: C51H79NO13
• Pharmacological Class: Selective Mechanistic Target of Rapamycin (mTOR) inhibitor
• Marketed By: Asher Pharmaceuticals, Pune, India
• Company Profile: Asher Pharmaceuticals is an Indian-based pharmaceutical enterprise involved in sourcing, marketing, and commercializing high-quality generic drugs, therapeutic formulations, and niche life-extension compounds under stringent quality regulatory guidelines to meet international market demands.

Anti-Aging & Longevity Properties (Geroprotection)

In modern longevity medicine, sirolimus (rapamycin) is recognized as one of the most thoroughly researched and promising geroprotectors. Rather than merely masking the superficial signs of aging, it targets the fundamental cellular mechanisms driven by the aging process.

1. mTORC1 Pathway Inhibition

The mTOR complex regulates cell growth and metabolism. Over time, its chronic hyperactivation leads to the accumulation of cellular waste and accelerated tissue aging. Siroash 3 downregulates overactive mTORC1 signaling, mimicking the biological benefits of caloric restriction to slow down the pace of biological aging.

2. Activation of Autophagy

By inhibiting the mTOR pathway, the drug triggers autophagy—the cell's natural "recycling" system. This process clears out damaged proteins, dysfunctional mitochondria, and toxic metabolic debris, effectively rejuvenating tissues at a cellular level.

3. Reduction of Systemic Inflammation (SASP)

Rapamycin effectively suppresses the Senescence-Associated Secretory Phenotype (SASP). It reduces the production of pro-inflammatory cytokines by senescent ("zombie") cells, thereby mitigating inflammaging—the chronic, low-grade inflammation that underlies most age-related diseases.

4. Metabolic and Cognitive Preservation

In longevity regimens, sirolimus is utilized to help optimize insulin sensitivity, support cardiovascular health against age-related arterial stiffness, and maintain neuroplasticity to protect the brain from cognitive decline.

Administration in Longevity Protocols

Unlike its high-dose daily use in transplantation medicine, anti-aging protocols typically employ rapamycin in intermittent, low-dose schedules (e.g., 3 mg to 6 mg taken once weekly or every two weeks). This pulse-dosing strategy is designed to maximize geroprotective benefits while avoiding chronic immune suppression and minimizing potential side effects.

For Research Applications Only. Disclaimer: The use of sirolimus for longevity purposes should always be conducted under the supervision of a qualified anti-aging specialist or physician, alongside regular blood work panels (including lipid profiles, glucose levels, and complete blood counts).