Niclosamide (Gerontis) 700 mg – 60 Capsules

Niclosamide — 60 Capsules (1 Bottle)

General Pharmaceutical & Chemical Information

• Active Ingredient: Niclosamide
• Dosage: 700 mg of Niclosamide per capsule
• Bulking Agent: Microcrystalline Cellulose (MCC)
• Capsule Shell: Gelatin
• Package Size: 1 Bottle (60 capsules)
• CAS Number: 50-65-7
• Molecular Formula: C13H8Cl2N2O4
• Form: Small-molecule compound enclosed in capsules with MCC bulking agent
• Application: For Research Applications Only.

Primary Therapeutic Focus: Oncology Prevention and Management

The primary and most significant application of Niclosamide in advanced research lies in its profound potential for cancer prevention and therapeutic intervention in oncology. Emerging biomedical data has highlighted this compound as a multi-targeted anti-tumor agent with exceptional pathway-modulating capabilities.

• Mitochondrial Uncoupling & Energy Stress: Niclosamide disrupts mitochondrial oxidative phosphorylation, reducing ATP production. This creates a severe energy crisis specifically within rapidly proliferating malignant cells.
• Cancer Cell Selectivity: It preferentially impacts metabolically active and glycolysis-dependent tumor cells in experimental models, demonstrating significantly reduced adverse effects on normal, healthy cells.
• Wnt/β-Catenin Pathway Inhibition: The compound demonstrates strong suppression of Wnt signaling—a critical cellular pathway that is frequently upregulated in active tumor growth and cancer stem cell maintenance.
• STAT3 Signaling Disruption: Niclosamide inhibits STAT3 phosphorylation, directly interfering with the transcription of genes deeply involved in the survival, resistance, and uncontrolled proliferation of malignant cells.
• mTOR and NF-κB Modulation: It downregulates key survival and inflammatory signaling pathways linked to tumor progression, angiogenesis, and established treatment resistance mechanisms.

Anti-Aging & Longevity Properties (Geroprotection & Senolysis)

Beyond its primary oncological indications, Niclosamide acts as a potent metabolic and cellular modulator within advanced longevity strategies.

• Induction of Autophagy: By inducing mild mitochondrial stress and altering the ATP/AMP ratio, it triggers cellular autophagy—the essential self-cleaning mechanism that clears out damaged proteins, dysfunctional mitochondria, and metabolic debris.
• Senomorphic & Anti-Inflammatory Effects: By modulating NF-κB and suppressing systemic inflammatory signaling, it helps mitigate the chronic, low-grade inflammation (inflammaging) that accelerates tissue degeneration and creates microenvironments permissive to age-related disease.

Administration & Strict Disclaimer

In advanced research frameworks, specialized metabolic and oncological compounds like Niclosamide are evaluated based on precise, protocol-defined timelines rather than unmonitored daily intake. A 60-capsule bottle provides an ideal supply for structured evaluation phases.

Strict Regulatory Disclaimer: This product is intended solely for laboratory research, in vitro evaluation, and analytical purposes. We do not provide medical advice, recommend specific protocols, or guarantee any therapeutic results. Nothing stated herein should be construed as a medical recommendation or a guarantee of efficacy in treating, curing, or preventing any disease, including cancer. Any practical application of this compound must be strictly validated by independent research and overseen by a qualified professional.