Metformin Prolonged 1000 mg, 90 Capsules

Metformin Prolonged — 90 Tablets (1 Bottle, 1000 mg)

This product listing features a complete bottle containing 90 extended-release (prolonged) tablets of Metformin (1000 mg each). The prolonged-release matrix ensures gradual, sustained active release, minimizing gastrointestinal side effects and providing a stable compound concentration for advanced off-label oncology prevention, metabolic modeling, and longevity research protocols.

General Pharmaceutical & Chemical Information

• Active Ingredient: Metformin Hydrochloride (Metformin HCl Prolonged / Extended Release)
• Dosage: 1000 mg of Metformin HCl per prolonged-release tablet
• Package Size: 1 Bottle (90 tablets)
• CAS Number: 1115-70-4 (Metformin HCl) / 657-24-9 (Metformin free base)
• Molecular Formula: C₄H₁₁N₅·HCl
• Form: Prolonged-release oral tablets
• Application: For Research Applications Only.

Primary Off-Label Focus: Oncology Prevention & Adjuvant Therapy

In proactive oncology and drug repurposing, Metformin Prolonged is heavily utilized for its multi-layered ability to disrupt cancer bioenergetics, starve malignant cells, and suppress tumor growth signaling without spiking peak plasma levels.

• Reversal of the Warburg Effect & Complex I Inhibition: Metformin mildly inhibits Complex I of the mitochondrial electron transport chain. In fast-dividing cancer cells, this reduces ATP production and forces cellular energetic stress. The extended-release profile provides continuous metabolic pressure on malignant tissues, preventing recovery.
• Indirect Systemic Starvation (Insulin/IGF-1 Axis Downregulation): Hyperinsulinemia acts as a direct growth factor for pre-cancerous and cancerous lesions via insulin and IGF-1 (Insulin-like Growth Factor 1) receptors. By enhancing peripheral insulin sensitivity and suppressing hepatic gluconeogenesis, Metformin starves insulin-dependent tumor populations.
• mTORC1 Pathway Suppression via AMPK: By activating AMP-activated protein kinase (AMPK) — the cell's master energy sensor — Metformin indirectly downregulates the hyperactive mTORC1 pathway in malignant cell populations, suppressing protein synthesis, cell growth, and clonal proliferation.
• Targeting Cancer Stem Cells (CSCs): Metformin selectively inhibits the survival and self-renewal pathways of cancer stem cells, reducing the likelihood of tumor recurrence, chemoresistance, and metastatic dissemination in adjuvant research protocols.

Anti-Aging & Longevity Properties (Geroprotection)

Metformin is widely regarded as a primary candidate geroprotector. The prolonged-release formulation provides steady AMPK activation to drive fundamental anti-aging mechanisms:

• Caloric Restriction Mimicry: Continuous AMPK stimulation mimics the metabolic pathways triggered by fasting, shifting tissues from nutrient-sensing growth states toward maintenance, cellular repair, and defense against systemic degradation.
• Mitigation of Inflammaging & Glycation: By maintaining steady-state blood glucose levels, Metformin prevents postprandial glycemic spikes that generate toxic advanced glycation end-products (AGEs). It also lowers chronic, low-grade systemic inflammation (inflammaging) by suppressing pro-inflammatory secretome profiles.
• Mitochondrial Protection & ROS Reduction: Mild Complex I modulation alters the intracellular redox state and limits the excessive production of damaging Reactive Oxygen Species (ROS), protecting structural DNA and organelle integrity over time.

Administration, Storage & Strict Disclaimer

Prolonged-release formulations are designed to deliver steady active tissue exposure with significantly improved gastrointestinal tolerability compared to immediate-release forms.

• Storage & Handling: Store in a cool, dry environment, away from heat, moisture, and direct sunlight, at controlled room temperature (15–25°C). Keep container tightly closed when not in use. Do not freeze.

Strict Regulatory Disclaimer: This product is intended solely for laboratory research, in vitro evaluation, and analytical purposes. We do not provide medical advice, recommend specific protocols, or guarantee any therapeutic results. Nothing stated herein should be construed as a medical recommendation or a guarantee of efficacy in treating, curing, or preventing any disease, including cancer. Any practical application of this compound must be strictly validated by independent research and overseen by a qualified professional.